How To

RE2: All lock and safe combos

February 8, 2019
Updated: July 2, 2025 at 5:24 AM

Resident Evil 2 is just as much of a puzzle game as it is a survival horror game. As you fight for your survival against the zombie hordes, you’re bound to come up against some locked safes and doors that contain all sorts of useful supplies. The solutions and combos, however, aren’t easy to find. If you’re hurting for supplies and don’t have time to hunt down those elusive codes, check out our guide to find out how to open all the locks and safes in the game.

RE2: All lock and safe combos

Waiting Room Safe

resident evil 2 lobby safe — Image courtesy Capcom

Location: Waiting Room (second floor, east wing)

Combo: Left 6, Right 2, Left 12- this combo can be found in the Confiscation Report document.

Contents: Matilda muzzle break (Leon), JMB Hp3 high capacity mag (Claire)

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Men’s Locker Room Locker

resident evil 2 shower room locker — Image courtesy Capcom

Location: Men’s Locker Room (second floor, west wing)

Combo: CAP- written on a whiteboard in the Operations Room storage area

Contents: Shotgun Shells (Leon), Flame Rounds (Claire)

3F Hallway Locker

resident evil 2 3f locker — Image courtesy Capcom

Location: Northwestern staircase, top floor

Combo: DCM- obtained via a film roll

Contents: Magnum Ammo (Leon), Submachine Gun Ammo (Claire)

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West Office Safe

Location: West Office, first floor

Combo: Left 9, Right 15, Left 7- found in the S.T.A.R.S. Office Memo

Contents: Hip Pouch (both characters)

Leon’s Desk Puzzle

re2 west office desk — Image courtesy Capcom

Location: West Office, first floor

Combo: NED (left lock), MRG (right lock)- found by inputting first initials of all officer’s names for each side of the room

Contents: Matilda High Capacity Mag (Leon), SLS-60 Speed Loader (Claire)

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Control Room Locker

Location: Control Room, sewer area

Combo: SZM- found via circled letters in Jazz Festival Flyer

Contents: Magnum Ammo (Leon), Submachine Gun Ammo (Claire)

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Treatment Pool Safe

Location: Treatment Pool Room, sewer area

Combo: Left 2, Right 12, Left 8- written on the side of the safe in chalk

Contents: W-870 Shotgun Stock (Leon), SLS-60 Reinforced Frame (Claire)

Alex LaFreniere

Alex's first experience with video games came at the tender young age of 12, when his parents gave him and his brothers a PlayStation 2 for Christmas. They’ve probably been regretting that mistake ever since, because as soon he finished his first lap in Gran Turismo 3, Alex was hooked for life. In addition to writing for Softonic, Alex has turned that love of games into a voice acting career, and has voiced everything from grizzled old soldiers to vampire lords. When he's not gaming or getting behind the microphone, Alex can probably be found wandering the woods around Boston or putting together some new culinary delight in his kitchen.